MUCOSAL TRANSMISSIBILITY, DISEASE INDUCTION AND CORECEPTOR SWITCHING OF R5 SHIVSF162P3N MOLECULAR CLONES IN RHESUS MACAQUES

Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaques

Abstract Background Mucosally transmissible and pathogenic CCR5 (R5)-tropic simian-human immunodeficiency virus MOST25 Pre-Amp (SHIV) molecular clones are useful reagents to identity neutralization escape in HIV-1 vaccine experiments and to study the envelope evolutionary process and mechanistic basis for coreceptor switch during the course of natu

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A combination of LongSAGE with Solexa sequencing is well suited to explore the depth and the complexity of transcriptome

Abstract Background "Open" transcriptome analysis methods allow to study gene expression without a priori knowledge of the transcript sequences.As of now, SAGE (Serial Analysis of Gene Expression), LongSAGE and MPSS (Massively Parallel Signature Sequencing) are the mostly used methods for "open" transcriptome analysis.Both LongSAGE and MPSS rely on

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